Tamoxifen-DNA adduct formation in monkey and human reproductive organs
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چکیده
منابع مشابه
Tamoxifen-DNA Adduct Formation in Rat Liver Determined by Immunoassay and P-Postlabeling
Tamoxifen (TAM), a nonsteroidal antiestrogen used as a chemotherapeutic and chemopreventive agent for breast cancer, induces liver tumors in rodents and covalent DNA adduct formation in hepatic DNA. Here, we report the development and validation of highly sensitive and specific immunoassays for the determination of TAM-DNA adducts. Rabbits were immunized with calf thymus DNA, chemically modifie...
متن کاملTamoxifen-DNA adduct formation in rat liver determined by immunoassay and 32P-postlabeling.
Tamoxifen (TAM), a nonsteroidal antiestrogen used as a chemotherapeutic and chemopreventive agent for breast cancer, induces liver tumors in rodents and covalent DNA adduct formation in hepatic DNA. Here, we report the development and validation of highly sensitive and specific immunoassays for the determination of TAM-DNA adducts. Rabbits were immunized with calf thymus DNA, chemically modifie...
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The beneficial effects of tamoxifen in the prevention and treatment of breast cancer are compromised by an increased risk of endometrial polyps, hyperplasia, and cancer. Tamoxifen is metabolized to an array of metabolites with estrogenic effects but also to reactive intermediates that may form protein and DNA adducts. The aim of this study was to investigate cellular [(3)H]tamoxifen adduct form...
متن کاملInvestigation of DNA Integration into Reproductive Organs Following Intramuscular Injection of DNA in Mice
Background: DNA immunization with plasmid DNA encoding bacterial, viral, parasitic, and tumor antigens has been reported to trigger protective immunity. The use of plasmid DNA vaccinations against many diseases has produced promising results in animal and human clinical trials; however, safety concerns about the use of DNA vaccines exist, such as the possibility of integration into the host gen...
متن کاملRelationships between DNA adduct formation and carcinogenesis.
An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific differences in carcinogenesis to establish the correlations. More recently, we have investigated similar relationships between target and nontarget cell populations within the liver. Chronic exposure to me...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2014
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/bgu029